Synthesis of Tadalafil Analogues

Liu‐Tang Wang West China School of Pharmacy, Sichuan University, Chengdu, China

Hao Huang Chengdu College of Education, Chengdu, China

Zhong‐Lin Ye Department of Research and Development Di'ao Co. Ltd, Chengdu, China

Yong Wu West China School of Pharmacy, Sichuan University, Chengdu, China

Xue‐Chao Wang Department of Research and Development Di'ao Co. Ltd, Chengdu, China

Abstract

Five novel compounds as potential phosphodiesterase type 5 (PDE‐5) inhibitors were synthesized from D‐tryptophan methyl ester via the Pictet–Spengler reaction and cyclization reaction. The structures of those compounds were confirmed by elemental analyses, IR, ¹H NMR, and ESI‐MS spectra.

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Synthesis of Tadalafil Analogues

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Synthesis of Tadalafil Analogues

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