Abstract
Pyrazolopyrimidine and pyrimidopyrimidine derivatives have shown a wide range of biological activities such as acting as A1 adenosine receptors, kinase insert domain receptor (KDR), Rous sarcoma oncogene (Src), epidermal growth factor receptor (EGFR), antiproliferative, dihydrofolate reductase (DHFR), antimicrobial, antifungal, and lipid peroxidation. Because of this wide range of activities, we have synthesized pyrazolo[3,4‐d]pyrimidines and pyrimido[4,5‐d]pyrimidin‐4‐one derivatives.
Keywords:
Acknowledgments
S. B. K. and A. K. thank the Council of Scientific and Industrial Research (India) for the award of fellowships. We are also thankful to Sophisticated Analytical Instrument Facility (SAIF) Division, Central Drug Research Institute (CDRI), Lucknow, for providing spectroscopic data (CDRI Communication No. 6858).