Convenient Synthesis of Oxazolidinones and Oxazinones from Allyl and Homoallyl Amines under Mild Conditions

Abstract

An efficient one‐pot general method for the high‐yield synthesis in solution of oxazolidinones and oxazinones from allyl‐ and homoallylamines, respectively, has been developed. The reaction is carried out at an atmospheric pressure between 0°C and room temperature using a solution of carbon dioxide in acetonitrile and hindered guanidine as the base.

Keywords:

• Carbon dioxide
• iodine
• oxazinones
• oxazolidinones

Acknowledgments

L. M. thanks the Ministerio de Educación (BQU2002‐02807) and the Xunta de Galicia (PGIDIT03PXIC30107PN) for financial support. E. G.‐E. is grateful to the Xunta de Galicia for a fellowship.