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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 20
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Original Articles

Ionic Liquid–Mediated Knoevenagel Condensation of Meldrum's Acid and Aldehydes

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Pages 3043-3051 | Received 30 Mar 2006, Published online: 16 Feb 2007
 

Abstract

A simple, efficient, and green protocol for Knoevenagel condensation of Meldrum's acid and aldehydes in ionic liquid at room temperature without any catalyst is described. The reaction has been performed in different ionic liquids. The enhancement in the rate is observed in Brönsted acidic ionic liquid 1‐methylimidazolium trifluoroacetate [Hmim]Tfa, which furnishes quantitative yields with 4–30 min in most of the cases. Furthermore, ionic liquid is easily reused without any appreciable loss in activity.

Acknowledgments

The authors are thankful to the Council of Scientific and Industrial Research and the Department of Science and Technology (New Delhi) for the financial support. N. B. D. and S. V. B. are thankful to CSIR for the award of junior research fellowships.

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