Efficient Synthesis of β‐Amino Alcohols Catalyzed by Niobium Pentachloride: Regioselective Ring Opening of Epoxides with Aromatic Amines

Abstract

Epoxides undergo a rapid ring‐opening reaction with aromatic amines catalyzed by niobium pentachloride under mild reaction conditions. All the reactions were carried out at room temperature to afford the corresponding β‐amino alcohols in excellent yields and with high regioselectivity.

IICT Communication No. 050916

Keywords:

• Aromatic amines
• β‐amino alcohols
• epoxides
• niobium pentachloride

Acknowledgment

D. S. thanks Council of Scientific & Industrial Research (CSIR), New Delhi, for providing a fellowship.

Notes

IICT Communication No. 050916