Preparation and Purification of Desethylamiodarone Hydrochloride

Anthony N. Lucas Center for Drug Delivery Research, University of Kansas, Lawrence, Kansas, USA

Mehmet Tanol Center for Drug Delivery Research, University of Kansas, Lawrence, Kansas, USA

Michelle P. McIntosh Center for Drug Delivery Research, University of Kansas, Lawrence, Kansas, USA

Roger A. Rajewski Center for Drug Delivery Research, University of Kansas, Lawrence, Kansas, USACorrespondence[email protected]

Abstract

Reaction of the free base of amiodarone with 1‐chloroethyl chloroformate in toluene gives desethylamiodarone, which can be easily purified and converted to the hydrochloride salt.

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Acknowledgment

This work was supported in part by a grant from the Kansas Technology Enterprise Corporation through the Centers for Excellence Program.

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Preparation and Purification of Desethylamiodarone Hydrochloride

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Preparation and Purification of Desethylamiodarone Hydrochloride

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