Synthesis of 7‐Sulfamoyl‐substituted 2‐Oxo‐2,3,4,5‐tetrahydro‐1H‐benzo[b]azepines

Abstract

Sulfochlorination of 2‐оxo‐2,3,4,5‐tetrahydro‐1H‐benzo[b]azepine led to regioselective formation of the corresponding 7‐chlorosulfonyl derivative. Starting from this reagent, a large number of substituted 2‐oxo‐7‐sulfamoyl‐2,3,4,5‐tetrahydro‐1H‐benzo[b]azepines were obtained. This approach is amenable to combinatorial production of the title compounds, which possess promising therapeutic potential.

Keywords:

• Benzoazepines
• combinatorial synthesis
• regioselective reaction
• sulfonamides

Acknowledgments

The authors thank Konstantin V. Balakin (ChemDiv, Inc.) for discussion and help in preparation of the manuscript.