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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 23
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Original Articles

Synthesis of 7‐Sulfamoyl‐substituted 2‐Oxo‐2,3,4,5‐tetrahydro‐1H‐benzo[b]azepines

, , , , &
Pages 3525-3535 | Received 20 Apr 2006, Published online: 24 Nov 2006
 

Abstract

Sulfochlorination of 2‐оxo‐2,3,4,5‐tetrahydro‐1H‐benzo[b]azepine led to regioselective formation of the corresponding 7‐chlorosulfonyl derivative. Starting from this reagent, a large number of substituted 2‐oxo‐7‐sulfamoyl‐2,3,4,5‐tetrahydro‐1H‐benzo[b]azepines were obtained. This approach is amenable to combinatorial production of the title compounds, which possess promising therapeutic potential.

Acknowledgments

The authors thank Konstantin V. Balakin (ChemDiv, Inc.) for discussion and help in preparation of the manuscript.

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