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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 23
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Original Articles

Regioselective N‐Arylation of Some Pyrimidine and Purine Nucleobases

, , , &
Pages 3549-3562 | Received 04 May 2006, Published online: 24 Nov 2006
 

Abstract

N‐Arylation of some pyrimidine and purine nucleobases in the presence of SiO2 and Cs2CO3 under solvent‐free as well as in solution conditions is described. In these conditions, N1‐aryl pyrimidines and N9‐aryl purines have been obtained regioselectively in moderate to high yields with relatively short reaction times.

Acknowledgments

We thank the Shiraz University and Shiraz University of Technology Research Councils for financial support of this work. We are also grateful to H. Sharghi for helpful discussion, and H. Sajedian Fard for running the NMR spectra.

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