New Protocol to Synthesize Spiro‐1,4‐dihydropyridines by Using a Multicomponent Reaction of Cyclohexanone, Ethyl Cyanoacetate, Isatin, and Primary Amines under Microwave Irradiation

Abstract

Series of some new spiro‐1,4‐dihydropyridine derivatives have been synthesized in good yields in a four‐component, solvent‐free process by condensation of isatins, primary amines, ethyl cyanoacetate, and cyclohexanone under microwave irradiation.

Keywords:

• Microwave irradiation
• multicomponent
• spiro‐1,4‐dihydropyridine
• synthesis