Synthesis of New Quinoline Derivatives

Judit Tóth Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, Budapest, Hungary

Gábor Blaskó EGIS Pharmaceuticals Ltd., Budapest, Hungary

András Dancsó EGIS Pharmaceuticals Ltd., Budapest, Hungary

László Tőke Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, Budapest, Hungary

Miklós Nyerges Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, Budapest, HungaryCorrespondence[email protected]

Abstract

The synthesis of some new functionalized quinolyl derivatives has been described, based on the 1,3‐dipolar cycloaddition of an azomethine ylide, generated from sarcosine or N‐benzylglycine and paraformaldehyde, to 2‐chloro‐3‐quinolinecarbaldehydes.

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Acknowledgments

This work was financially supported by the National Fund for Science and Research, Hungary (OTKA Project No. T 046196). N. M. thanks the Hungarian Academy of Sciences for a Bolyai J. Fellowship. A grant from the József Varga Foundation provided to J. T. is gratefully appreciated.

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Synthesis of New Quinoline Derivatives

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