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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 23
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Original Articles

Efficient and Mild Procedure for Reductive Methylation of Amines Using N‐Methylpiperidine Zinc Borohydride

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Pages 3609-3615 | Received 02 Feb 2006, Published online: 24 Nov 2006
 

Abstract

A simple and efficient procedure for reductive methylation of primary and secondary amines using N‐methylpiperidine zinc borohydride (ZBNMPP), giving tertiary amines, is described. The reaction is carried out in methanol at room temperature under neutral conditions.

Acknowledgment

Financial support of this work from the Research Council of Mazandaran University is gratefully acknowledged.

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