Rapid Synthesis of New 5‐Nitroimidazoles as Potential Antibacterial Drugs via VNS Procedure

Abstract

Original 4‐arylsulfonylmethyl‐5‐nitroimidazoles were prepared by reacting four chloromethylaryl sulfones with 5‐nitroimidazole derivatives via a vicarious nucleophilic substitution (VNS) of hydrogen reaction.

Keywords:

• Chloromethyl sulfone
• 5‐nitroimidazole
• sulfinate anion
• VNS

Acknowledgments

This work has been supported by the Centre National de la Recherche Scientifique and the Universities of Aix‐Marseille. Authors thank C. Chapuis for technical support.