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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 24
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Original Articles

Studies on Spiroheterocycles, Part II: Heterocyclization of the Spiro Compounds Containing Cyclohexanone and Thiobarbituric Acid with Different Bidentate Nucleophilic Reagents

, , , &
Pages 3729-3742 | Received 08 May 2006, Published online: 01 Dec 2006
 

Abstract

The reaction of thiobarbituric acid with different diarylidene ketones 1ac yields the spiro compounds 2ac. The diarylidene derivatives 3ac are synthesized by the condensation of spiro compounds 2a–c with different aldehydes. A series of spiro heterocycles compounds 4al, 5al, 6al, 7al, 8al, and 9al are synthesized from the diarylidene compounds. The structures of the compounds are ascertained from their analytical and spectral data. Some of the compounds are screened for their biological activities.

Acknowledgment

The authors thank the Department of Science and Technology, government of India, and University Grant Commission, New Delhi, for FIST and DRS support.

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