Novel Approach to the Synthesis of (R,S)‐Baclofen via PD(II)‐Bipyridine–Catalyzed Conjugative Addition

Abstract

Synthesis of (R,S)‐baclofen is described starting from N‐phthalimidoacetaldehyde. The key step in the synthesis was Pd(II)‐bipyridine–catalyzed conjugative addition of 4‐chloroboronic acid.

IICT Communication No. 051225.

Keywords:

• Allylphthalimide
• baclofen
• N‐phthalimidoacetaldehyde
• ozonolysis
• Pd(II)‐bipy

Acknowledgments

V. R. is thankful to the DIICT, J. S. Yadav, and also CSIR, India, for the award of the fellowship.

Notes

IICT Communication No. 051225.