Efficient Method for the Synthesis of 1,5‐Benzodiazepine Derivatives Catalyzed by Monoammonium Salt of 12‐Tungstophosphoric Acid

Abstract

Monoammonium salt of 12‐tungstophosphoric acid [(NH₄)H₂PW₁₂O₄₀] was found to be a practical, inexpensive, reusable, and efficient heterogeneous catalyst for the preparation of 1,5‐benzodiazepine derivatives of o‐phenylenediamine and ketones. The heteropolyacid‐based catalyst has the advantages of simple workup procedure, water insolubility with good activity, and high‐yielding reaction for the synthesis of 1,5‐benzodiazepine derivatives.

IICT Communication No. 060112.

Keywords:

• Benzodiazepines
• monoammonium salt of 12‐tungstophosphoric acid
• o‐phenylenediamines

Notes

IICT Communication No. 060112.