One‐Pot Synthetic Procedure for2,2′‐Disubstituted Biaryls via the Suzuki Coupling Reaction of Aryl Triflates in a Biphasic Solvent System

Abstract

A one‐pot synthetic procedure for 2,2′‐disubstituted biaryls was developed via a Suzuki cross‐coupling reaction of aryl triflates in a biphasic solvent system. The effects of various bases and solvents were investigated. Results showed that the Na₂CO₃–toluene/H₂O combination gave the highest yields.

Keywords:

• Biphasic solvent
• 2,2′‐disubstituted biaryls
• one‐pot reaction
• Suzuki coupling reaction
• tetra(alkoxo)diboron

Acknowledgment

The authors acknowledge Yuji Koga for his many helpful discussions during the preparation of this manuscript. We are also grateful to the staff of the Division of Analytical Science Laboratories of Astellas Pharma Inc. for elemental analysis and spectral measurements.