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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 24
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Original Articles

Total Synthesis of 4″‐O‐Acetylmananthoside B, Part I: Synthesis and Tentative Ozonolysis of a Cyclohexadiene Derivative

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Pages 3821-3828 | Received 10 Apr 2006, Published online: 01 Dec 2006
 

Abstract

A cyclohexadiene derivative cis‐N,N‐diethyl‐2‐benzyloxymethyl‐1,2‐dihydrobenzamide 8 was constructed from γ‐butyrolactone I for the total synthesis of a natural product 4″‐O‐acetylmananthoside B, which was reported to display significant cytotoxic activity. Preliminary ozonolysis of 8 for further synthetic purposes was also carried out.

Acknowledgment

The authors express sincere gratitude to Guiyun Duan and Datong Zhang for their valuable discussions.

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