Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 1
52
Views
2
CrossRef citations to date
0
Altmetric
Abstracts

Graphical Abstracts

Pages 1-7 | Published online: 25 Jul 2007
 

Abstract

Graphical Abstract Section

Abstract

Synth. Commun. 2007, 37, 9

SYNTHESIS OF β-SECRETASE INHIBITORS CONTAINING A HYDROXYETHYLENE DIPEPTIDE ISOSTERE

Xiaoming Yang, Xiaomin Zou, Yiqiu Fu, Ke Mou, Gang Fu, Chao Ma, and Ping Xu

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China

A new β-secretase inhibito 17 was synthesized via two pathways, with detailed discussion and comparison of respective reation conditions and yields.

Abstract

Synth. Commun. 2007, 37, 25

L -PROLINE-PROMOTED CuI-CATALYZED C-S BOND FORMATION BETWEEN ARYL IODIDES AND THIOLS

Hui Zhang,1 Weiguo Cao,1,2 and Dawei Ma3

1Department of Chemistry, Shanghai University, Shanghai, China

2State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, China

3State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, China

An improved, mild procedure for the CuI-catalyzed coupling reactions of aryl iodides with aliphatic and aromatic thiols, using L-proline as the ligand, is reported.

Abstract

Synth. Commun. 2007, 37, 37

FACILE AND EFFICIENT WAY TO SYNTHESIZE THE RADICAL CYCLIZATION PRECURSOR METHYL 3-(TERT-BUTYL((E)-3-(2,2-DIPHENYLCYCLOPROPYL)-2-PROPENYL)AMINO)-3-OXO-2-(PHENYLSELENO)PROPANOATE FOR KINETIC RESEARCH

Jindi Yu, Gaoyan Lian, and Danwei Zhang

Department of Chemistry, Fudan University, Shanghai, China

Abstract

Synth. Commun. 2007, 37, 47

EFFICIENT BIGINELLI REACTION CATALYZED BY SULFAMIC ACID OR SILICA SULFURIC ACID UNDER SOLVENT-FREE CONDITIONS

Wei-Yi Chen,1 Su-Dong Qin,2 and Jian-Rong Jin1

1College of Chemistry and Chemical Engineering of Suzhou University, Suzhou, China

2Technical Department of JiangShan Pharmaceutical Corporation, JingJiang, China

Sulfamic acid efficiently catalyzes the three-component condensation reaction of aldehydes, 1,3-dicarbonyl compounds, and urea/thiourea under solvent-free conditions to afford the corresponding dihydropyrimidinones and thio-derivatives in high yields. Silica sulfuric acid is also found to be an efficient catalyst for the Biginelli reaction under solvent-free conditions. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of giving good yields and requiring short reaction times.

Abstract

Synth. Commun. 2007, 37, 53

NEW STRAIGHTFORWARD SYNTHESIS OF 2-AMINO-6-METHYL-5-(PYRIDIN-4-YLSULFANYL)-3H-QUINAZOLIN-4-ONE

Wei-Min Chen,1,2 and Shan-He Wan2

1Department of Medicinal Chemistry, School of Pharmacy, Jinan University, Guangzhou, China

2Institute of Pharmaceutical Sciences, First Military Medical University, Guangzhou, China

2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quinazolin-4-one (1) was synthesized with 2-guanidino-5-bromo-6-methylquinazolin-4-one (6) as the key intermediate in a one-pot synthesis by treatment of compound 6 with 4-mercaptopyridine and KOH. 4-Mercaptopyridine was found to play the role of protecting agent to prevent -Br on a quinazoline ring from being substituted by -OH.

Abstract

Synth. Commun. 2007, 37, 63

CONCISE AND EFFICIENT SYNTHESIS OF LINEAR FUROCOUMARINS: PSORALEN AND 4-METHYLPSORALEN

Bang-Le Zhang,1,2 Fang-Dao Wang,1 and Jian-Min Yue1

1State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

2School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China

A method for the rapid synthesis of psoralen and 4-methylpsoralen has been developed. The key intermediates, coumarinyloxyaldehydes, were obtained in only two steps from the easily available starting materials, 7-hydroxycoumarin derivatives, by an oxidative procedure. Using Swern oxidation, psoralen and 4-methylpsoralen were finally produced in the overall yields of 71% and 67%, respectively.

Abstract

Synth. Commun. 2007, 37, 71

SYNTHESIS AND STRUCTURE OF NOVEL DISULFIDE(TRISULFIDE)-CONTAINING THIOPHENES

Shi-Ren Deng,1 Tao Wu,2 Gao-Qiang Hu,1 Dan Li,2 Yun-Hong Zhou,1 and Zao-Ying Li1

1Department of Chemistry, Wuhan University, Wuhan, China

2Department of Chemistry, Shantou University, Shantou, China

Abstract

Synth. Commun. 2007, 37, 79

DESIGN AND SYNTHESES OF NOVEL CALIX[4](AZA)CROWNS: NEUTRAL RECEPTORS FOR α‐AMINO ACIDS

Fafu Yang,1 Yanqing Ji,1 Hongyu Guo,1 Jianrong Lin,1 and Qi Peng2

1College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, China

2State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China

Series of novel calix[4](aza)crowns 2a2d countaining acylhydrazone groups were synthesized and showed good complexation abilities towards α-amino acids.

Abstract

Synth. Commun. 2007, 37, 87

EFFICIENT α-CHLORINATION AND α-BROMINATION OF CARBONYL COMPOUNDS USING N-HALOSUCCINIMIDES/UHP IN IONIC LIQUID

Jong Chan Lee and Hyun Jung Park

Department of Chemistry, Chung-Ang University, Seoul, South Korea

A novel method is developed for the transformation of aryl ketones into their corresponding α-haloaryl ketones using NXS and UHP in [bmim]BF4

Abstract

Synth. Commun. 2007, 37, 91

L-PROLINE-CATALYZED MICHAEL ADDITION OF ALDEHYDES AND UNMODIFIED KETONES TO NITRO OLEFINS ACCELERATED BY Et3N

B. M. Choudary,1 Ch. V. Rajasekhar,2 G. Gopi Krishna,2 and K. Rajender Reddy2

1Ogene Systems (I) Pvt. Ltd., Hyderabad, India

2Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, India

Abstract

Synth. Commun. 2007, 37, 99

INTRAMOLECULAR AMIDATION: SYNTHESIS OF NOVEL THIAZOLE-FUSED DIAZEPINONES

Rajesh S. Koti, Gundurao D. Kolavi, Vinayak S. Hegde, and Imtiyaz Ahmed M. Khazi

Department of Chemistry, Karnatak University, Dharwad, India

A new fused heterocycile system, thiazolodiazepinone, is synthesized by applying intramolecular hydrazonolysis to 2-coumarinyl-5-formylthiazole.

Abstract

Synth. Commun. 2007, 37, 107

A SIMPLE AND CONVENIENT SYNTHESIS OF PYRAZINONES

Saikat Das Sharma, Pranjal Gogoi, and Dilip Konwar

Synthetic Organic Chemistry Division, Regional Research Laboratory, Jorhat, Assam, India

Abstract

Synth. Commun. 2007, 37, 113

REACTION OF β‐LAPACHONE WITH 1,2‐DIAMINES: FACILE SYNTHESIS OF NOVEL TETRACYCLIC PYRAZINES

Pahup Singh,1 Anshu Dandia,1 Kavita Natani,1 Venu Sharma,1 Raju Ratnani,2 A. L. Bingham,3 M. B. Hursthouse,3 M. E. Light,3 and J. E. Drake4

1Department of Chemistry, University of Rajasthan, Jaipur 302004 India

2Department of Pure and Applied Chemistry, M.D.S. University, Ajmer, India

3Department of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

4Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada

Abstract

Synth. Commun. 2007, 37, 119

FACILE SOLID-PHASE SYNTHESIS OF CYCLOALKYLPHOSPHONATES AND 1-CYCLOALKENYLPHOSPHONATES USING POLYMER-SUPPORTED PHENYLSULFONYLMETHYLPHOSPHONATES

Xiao-Ling Liu, Shou-Ri Sheng, Wei Zhou, Qiu-Ying Wang, Xiao-Lan Zhang, and Bin Gong

College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, China

A facile procedure for the solid-phase synthesis of cycloalkylphosphonates and 1-cycloalkenylphosphonates in good yields and high purities using polystyrene-supported phenylsulfonylmethylphosphonates with traceless sulfone linker strategy is described.

Abstract

Synth. Commun. 2007, 37, 129

CONVENIENT SYNTHESIS OF AN N-(1-ALKOXYL-9-FLUORENYL)SERINE ACRIDINE CONJUGATE

Jifeng Dai and Qibing Zhou

Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA

Abstract

Synth. Commun. 2007, 37, 137

HALOGENATION OF PYRAZOLES USING N-HALOSUCCINIMIDES IN CCL4 AND IN WATER

Zhi-Gang Zhao and Zhong-Xia Wang

Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China

Reaction of pyrazoles with N-halosuccinimides (NXS, X=Cl, Br) in CCl4 or water gave 4-halopyrazoles in excellent yields. The reaction was carried out under mild conditions and did not require any catalysts or special precautions.

Abstract

Synth. Commun. 2007, 37, 149

TRANSFORMATION OF ARYL ACYLOIN O-ALKYL AND O-PHENYL DERIVATIVES TO KETONES

Zhiyi Yao,1 Deju Ye,1 Hong Liu,1 Kaixian Chen,1 and Hualiang Jian1,2

1Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai, China

2School of Pharmacy, East China University of Science and Technology, Shanghai, China

The treatment of aryl acyloin (α-hydroxyketone) O-alkyl and O-phenyl derivatives with 2–3 equiv of Zn and 1–2 equiv of NH4Cl in ethanol, refluxing for 20–120min, gave the corresponding ketones with excellent yields. Further, α,β-epoxy ketones can be efficiently transformed to β-hydroxy ketones, and 2,2-dialkoxy-1-phenyl ketone also can be dealkoxylated to 1-phenyl ketone.

Abstract

Synth. Commun. 2007, 37, 157

SYNTHESIS OF NOVEL NORCANTHARIDIN DERIVATIVES OF SUBSTITUTED AROMATIC AMINES WITH IMPROVED 1,3‐DIPOLAR CYCLOADDITION

Liping Deng and Yongzhou Hu

Zhejiang University, Department of Medicinal Chemistry, School of Pharmaceutical Science, Hangzhou, China

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.