Efficient Green Procedure for the Synthesis of Coumarin Derivatives by a One‐Pot, Three‐Component Reaction under Solvent‐Free Conditions

Liangce Rong Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu, China; Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu, ChinaCorrespondence[email protected]

Xiaoyue Li Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu, China

Haiying Wang Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu, China

Daqing Shi Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu, China; Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu, China

Shujiang Tu Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu, China; Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu, China

Qiya Zhuang Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu, China; Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu, China

Abstract

A simple, efficient, and general method has been developed for the synthesis of coumarin derivatives through a one‐pot reaction of aromatic aldehydes, 2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione and 5,5‐dimethyl‐1,3‐cyclohexanedione, in the presence of TEBA under solvent‐free conditions using grinding methods. The mild reaction conditions, simple protocol, high yields, and cleaner reaction make this protocol practical and economically attractive.

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Acknowledgments

We are grateful to the Natural Science Foundation (04XLB14) of Xuzhou Normal University for financial support.

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Efficient Green Procedure for the Synthesis of Coumarin Derivatives by a One‐Pot, Three‐Component Reaction under Solvent‐Free Conditions

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Efficient Green Procedure for the Synthesis of Coumarin Derivatives by a One‐Pot, Three‐Component Reaction under Solvent‐Free Conditions

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