Simple and Selective Removal of the t‐Butyloxycarbonyl (Boc) Protecting Group on Indoles, Pyrroles, Indazoles, and Carbolines

Abstract

A highly selective and efficient deprotection of the N‐t‐butoxy carbonyl (N‐Boc) group on indoles, pyrroles, indazoles, and carbolines has been achieved in high yields using a catalytic amount of NaOMe as a base in dry MeOH, at ambient temperature.

IICT Communication No. 060512.

Keywords:

• ±‐butyloxycarbonyl (BOC)
• indoles
• pyrroles
• indazoles
• carbolines
• sodium methoxide

Acknowledgments

K. R., A. V. R., and C. M. thank University Grants Commission (UGC), Council of Scientific and Industrial Research (CSIR), New Delhi, for providing fellowships, we thank Department of Ocean Development (DOD) for financial assistance, and we thank J. S. Yadav, director Indian Institute of Chemical Technology (IICT)‐Hyderabad, India, for his constant encouragement.

Notes

IICT Communication No. 060512.