Convenient and Regioselective One‐Pot Solvent‐Free Synthesis of ß‐Hydroxyphosphonates

Abstract

A simple, efficient, regioselective, and solvent‐free method has been developed for the synthesis of β‐hydroxyphosphonates from epoxides and triethyl phosphite using ZnCl₂ in high yields under mild conditions.

Keywords:

• epoxides
• β‐hydroxyphosphonates
• triethyl phosphite
• ZnCl₂

Acknowledgment

We gratefully acknowledge the support of this work by the Shiraz University research council.