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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 3
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Original Articles

New Route for Conversion of Camptothecin to 7‐Ethylcamptothecin and 7‐Propylcamptothecin

Xin Wang Department of Chemistry, College of Basic Medicine, Anhui Medical University, Hefei, Anhui, China
,
Xiaojing Wu School of Chemical Engineering, Hefei University of Technology, Hefei, Anhui, ChinaCorrespondence[email protected]
,
Ning Cheng School of Chemical Engineering, Hefei University of Technology, Hefei, Anhui, China
,
Huiqing Zhao Department of Chemistry, College of Basic Medicine, Anhui Medical University, Hefei, Anhui, China
,
Zhihong Gu Department of Chemistry, College of Basic Medicine, Anhui Medical University, Hefei, Anhui, China
&
Xiang Shen First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China
Pages 519-523 | Received 16 May 2006, Published online: 06 Feb 2007
 
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Abstract

In this article, a new route for conversion of camptothecin to 7‐ethylcamptothecin and 7‐propylcamptothecin is described. Compared with previous reports, the reaction time of the new synthetic route was greatly shortened to 30 min, and the products were obtained in high yield.

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