Application of Polymer‐Supported Triphenylphosphine and Microwave Irradiation to the Palladium‐Catalyzed Cyanation of Aryl Triflates

Rajiv R. Srivastava Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USACorrespondence[email protected]

Andrew J. Zych Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA

David M. Jenkins Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA

Hong‐Jun Wang Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA

Zhen‐Jia Chen, Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA

David J. Fairfax Department of Medicinal Chemistry, Albany Molecular Research, Inc., Albany, New York, USA

Abstract

A variety of aryl nitriles were prepared in excellent yield from the palladium(II) acetate–catalyzed cross‐coupling of aryl triflates and zinc cyanide under microwave irradiation conditions. To facilitate purification, polymer‐supported triphenylphosphine was used as the palladium ligand. Comparison to the corresponding thermal conditions revealed much shorter reaction times with comparable yields.

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Acknowledgments

The authors thank Brian T. Gregg and William G. Earley for helpful discussions.

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Application of Polymer‐Supported Triphenylphosphine and Microwave Irradiation to the Palladium‐Catalyzed Cyanation of Aryl Triflates

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Application of Polymer‐Supported Triphenylphosphine and Microwave Irradiation to the Palladium‐Catalyzed Cyanation of Aryl Triflates

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