One‐Pot, Three‐Component Condensation Reaction in Water: An Efficient and Improved Procedure for the Synthesis of Pyran Annulated Heterocyclic Systems

Abstract

Environmentally friendly three‐component condensation reactions of an activated C‐H acid, an aldehyde, and alkyl nitriles to afford the corresponding pyran annulated heterocyclic systems in water in good yields, avoiding the addition of any catalyst, are reported.

Keywords:

• 1,3‐dimethylbarbituric acid
• 4‐hydroxycoumarin
• 4‐hydroxy‐6‐methylpyrone
• pyran annulated heterocyclic system
• three‐component reaction
• water

Acknowledgment

We gratefully acknowledge the financial support from the Research Council of Shahid Beheshti University.