Efficient and Ecofriendly Protocol for Tetrahydropyranylation/Depyranylation of Alcohols in the Presence of Tin(II) Chloride Dihydrate

Abstract

A mild, efficient, and solvent‐free protocol for tetrahydropyranylation of alcohols in the presence of a catalytic amount of SnCl₂ · 2H₂O is reported. Simple filtration of the reaction mixture through a short silica‐gel pad gives the pure products in excellent yields. Depyranylation can also be achieved by adding methanol under similar reaction conditions.

Keywords:

• alcohols
• microwave
• solvent‐free
• tetrahydropyranylation

Acknowledgments

Authors are grateful to the vice‐chancellor, Dibrugarh University, for giving the facility to work. Thanks are also due to Nabin C. Baruah, Regional Research Laboratory, Jorhat, and P.K. Gogoi, Chemistry Department, D.U., for their valuable suggestions and help.