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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 4
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Original Articles

Triflouroacetic Acid as an Efficient Catalyst for the Synthesis of Quinoline

Ahmad Shaabani Department of Chemistry, Shahid Beheshti University, Tehran, IranCorrespondence[email protected]
,
Ebrahim Soleimani Department of Chemistry, Shahid Beheshti University, Tehran, Iran
&
Zahra Badri Department of Chemistry, Shahid Beheshti University, Tehran, Iran
Pages 629-635 | Received 08 Mar 2006, Published online: 06 Mar 2007
 
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Abstract

Triflouroacetic acid efficiently catalyzed the Friedländer synthesis of quinolines through a condensation reaction of an 2‐aminoaryl ketone with an activated α‐CH acid such as cyclic or acyclic β‐dicarbonyl or cyclic ketone compounds under solvent‐free conditions with high yields within several minutes.

Acknowledgment

We gratefully acknowledge the financial support from the Research Council of Shahid Beheshti University.

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Related Research Data

Regioselectivity of Friedländer Quinoline Syntheses
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