Convenient Synthesis of Bis(3‐indolyl)‐acetylene via Sonogashira Coupling

Abstract

We describe the synthesis of bis(3‐indolyl)acetylene 6 via a Pd‐catalyzed cross‐coupling reaction of iodoindole 8 and 3‐indolylacetylene 9, followed by deprotection of 14 to furnish 6.

Keywords:

• (indolyl)acetylenes
• iodoindoles
• Pd‐catalyzed reaction

Acknowledgments

This investigation was supported in part by the donors of the Petroleum Research Fund (PRF), administered by the American Chemical Society, and Wyeth.