One‐Pot Synthesis of 3,5‐Disubstituted Pyridin‐2‐ones by Annulation of β‐Keto‐amides with 2‐Dimethylaminomethylene‐1,3‐bis(dimethylimonio)propane Diperchlorate

Abstract

β‐Keto‐amides react with 2‐dimethylaminomethylene‐1,3‐bis(dimethylimonio)propane diperchlorate salt to give the corresponding 3‐acetyl‐5‐formylpyridin‐2‐ones. The annulation reactions proceed with excellent yields.

Keywords:

• annulation reaction
• disubstituted pyridin‐2‐ones
• 2‐iminovinamidinium salt
• β‐keto‐amides

Acknowledgments

The authors thank the DGRSRT (Direction Générale de la Recherche Scientifique et de la Rénovation Technologique) from the Tunisian Ministry of Higher Education for the financial support of the research.