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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 7
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Original Articles

Highly Enantioselective Hydrogenation of β‐Alkyl and β‐(ω‐Chloroalkyl) Substituted β‐Keto Esters

, , , , , & show all
Pages 1067-1076 | Received 23 Aug 2006, Published online: 13 Oct 2010
 

Abstract

Highly enantioselective hydrogenation of β‐alkyl and β‐(ω‐chloroalkyl) substituted β‐keto esters was achieved with Ru catalysts based on chiral diphosphines in EtOH at 50°C under 50‐bar initial hydrogen pressure, affording the corresponding β‐hydroxy esters in >98% ee.

Acknowledgments

We acknowledge financial support from Wirtschaftsministerium von Mecklenburg‐Vorpommern.

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