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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 7
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Original Articles

New Approach to 3‐Aminothiophene‐ 2‐carboxylic Acid Derivatives: Access to 5‐Aryl‐4‐(ethylsulfanyl) Compounds

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Pages 1133-1140 | Received 12 Jun 2006, Published online: 13 Oct 2010
 

Abstract

Treatment of DMSO/water solutions of β‐bromo‐α‐(ethylsulfanyl)cinnamonitriles with sodium sulphide and α‐halo acetic acids derivatives followed by cyclization in a potassium carbonate/acetone/DMSO mixture gave the expected 3‐amino‐5‐aryl‐4‐(ethylsulfanyl)thiophene‐2‐carboxylic acids derivatives in fair yields.

Acknowledgments

The authors are grateful to F. Mongin for many helpful discussions and to P. Guenot for recording mass spectra.

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