Silica Sulfuric Acid: An Efficient and Versatile Acidic Catalyst for the Rapid and Ecofriendly Synthesis of 1,3,4‐Oxadiazoles at Ambient Temperature

Minoo Dabiri Department of Chemistry, Faculty of Science, Shahid Beheshti University, Evin, Tehran, IranCorrespondence[email protected]

Peyman Salehi Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran

Mostafa Baghbanzadeh Department of Chemistry, Faculty of Science, Shahid Beheshti University, Evin, Tehran, Iran

Mohammad Ali Zolfigol Department of Chemistry, Faculty of Science, Bu‐Ali Sina University, Hamadan, Iran

Mahboobeh Bahramnejad Department of Chemistry, Faculty of Science, Shahid Beheshti University, Evin, Tehran, Iran

Abstract

A rapid and green synthesis of 2,5‐disubstituted 1,3,4‐oxadiazoles is reported. The title compounds were prepared by the reaction of different acyl hydrazides and orthoesters in the presence of silica sulfuric acid under solvent‐free conditions. In this new process, reactions were run at ambient temperature and completed in a short period of time with high yields.

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Acknowledgment

Financial support from the Research Council of Shahid Beheshti University is gratefully acknowledged.

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Silica Sulfuric Acid: An Efficient and Versatile Acidic Catalyst for the Rapid and Ecofriendly Synthesis of 1,3,4‐Oxadiazoles at Ambient Temperature

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Silica Sulfuric Acid: An Efficient and Versatile Acidic Catalyst for the Rapid and Ecofriendly Synthesis of 1,3,4‐Oxadiazoles at Ambient Temperature

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