Synthesis of 2‐Benzothienyl Carbonyl 4‐Arylpiperazines as Novel Delavirdine Analogs

Abstract

A novel series of 2‐benzothienyl carbonyl arylpiperazines (6a–f) was synthesized as potential HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs). Preparation of the derivatives was performed by reacting benzo[b]thiophene carbonyl chloride (5) with a series of substituted 4‐arylpiperazines.

Keywords:

• arylpiperazines
• benzothiophene
• delavirdine
• HIV‐1 reverse transcriptase inhibitors

Acknowledgments

We thank Proyectos Fondecyt 1050289–1050950 and Proyecto Cepedeq–Facultad, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.