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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 8
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Original Articles

Straightforward Synthesis of 2‐Aryl‐1‐alkynylphosphonates and Arylpropiolates

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Pages 1301-1311 | Received 04 Aug 2006, Published online: 12 Apr 2007
 

Abstract

A protocol for the direct cross coupling of trialkylsilyl‐alkynes bearing electron‐withdrawing groups and aryl halides using a Pd/Ag catalytic system is described. The procedure allows the straightforward synthesis of a variety of alkynylphosphonates and aryl propiolates derivatives in good yields.

Acknowledgment

This work was supported by the Nuclear Toxicology program of the CEA, for which grateful acknowledgment is made. We also thank E. Zekri and D. Buisson for experimental assistance with MS and LC/MS measurements.

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