Total Synthesis of Pulchellalactam via an RCM Strategy

Abstract

Total synthesis of (Z) pulchellalactam, a CD protein tyrosine phosphatase inhibitor, from commercially available methallyl chloride employing ring‐closure metathesis (RCM) as a key step is described.

Keywords:

• alkaloid
• natural products
• pulchellalactam
• RCM
• total synthesis

Acknowledgments

A. B. P. and A. N. D. thank Council of Scientific and Industrial Research, New Delhi for a fellowship, and S. P. C. thanks Department of Science and Technology, New Delhi, for funding.