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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 9
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Original Articles

Rapid Method of Converting Primary Amides to Nitriles and Nitriles to Primary Amides by ZnCl2 using Microwaves under Different Reaction Conditions

Krishnappa Manjula Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, India
&
Mohamed Afzal Pasha Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, IndiaCorrespondence[email protected]
Pages 1545-1550 | Received 28 Sep 2006, Published online: 11 May 2007
 
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Abstract

A rapid and facile method for the conversion of primary amides to nitriles using inexpensive and readily available ZnCl2 in aqueous acetonitrile and their regeneration using ZnCl2–H2O–THF in the presence of acetamide under microwave irradiation in good yields is reported. The reactions go to completion within a minute.

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Related Research Data

Mechanistic Studies into Metal‐Catalyzed Aldoxime to Amide Rearrangements
Source: Wiley
Synthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile
Source: Royal Society of Chemistry (RSC)
Novel (cyanamide)ZnII complexes and zinc(II)-mediated hydration of the cyanamide ligands
Source: (:unav)
A general palladium-catalyzed aminocarbonylation of phenols to primary benzamides via in situ generation of aryl nonaflates.
Source: Wiley
Metal‐Free One‐Pot Conversion of Olefins and Alkynes to Amides Using TsNBr2, I2 and Aqueous NH3 at Room Temperature
Source: Wiley
Metal-Catalyzed Dehydration of Primary Amides to Nitriles
Source: Wiley
Lewis acid promoted dehydration of amides to nitriles catalyzed by [PSiP]‐pincer iron hydrides
Source: Wiley

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