Graphical Abstracts

Abstract

Graphical Abstract Section

Abstract

Synth. Commun. 2007, 37, 1227

SYNTHESIS OF 2-BENZOTHIENYL CARBONYL 4-ARYLPIPERAZINES AS NOVEL DELAVIRDINE ANALOGS

Hernán Pessoa-Mahana,¹ Rodrigo Acevedo R.,¹ Claudio Saitz B., Ramiro Araya-Maturana,¹ and C. D. Pessoa-Mahana²

¹Facultad de Ciencias Químicas y Farmacéuticas, Departamento de Química Orgánica y Fisicoquímica, Universidad de Chile, Santiago, Chile

²Departamento de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile

The synthesis of substituted 2-benzothienyl carbonyl 4-arylpiperazine derivatives 1, structurally related to the anti-HIV-1 delavirdine, is reported.

Abstract

Synth. Commun. 2007, 37, 1237

FACILE SYNTHESIS OF 3,3‐DIALKYL‐6‐PHENYL‐IMIDAZO‐PYRIDINONES

Weiqin Jiang, James J. Fiordeliso, Zhihua Sui

Johnson & Johnson Pharmaceutical Research & Development L.L.C., Drug Discovery, 1000 Route 202, Raritan, NJ 08869

A four-step synthetic pathway to novel 3,3‐dialkyl‐6‐phenyl‐imidazo‐pyridinones was described.

Abstract

Synth. Commun. 2007, 37, 1251

PHYTOCHEMICALS FROM ECHINACEA AND HYPERICUM: A DIRECT SYNTHESIS OF ISOLIGULARONE

George A. Krauss, Jaehoon Bae, and Junwon Kim

Department of Chemistry, Iowa State University, Ames, Iowa, USA

Reaction of trienes with α,β-unsaturated aldehydes produces bicyclic products via a tandem Diels–Alder/ene reaction. The adduct from tiglic aldehyde was converted into isoligularone by conversion to a furan followed by benzylic oxidation.

Abstract

Synth. Commun. 2007, 37, 1259

SOLVENT-FREE IODINATION OF ARENES USING IODINE–SILVER NITRATE COMBINATION

Mekhman S. Yusubov,^1,2 Elena N. Tveryakova,^1,2 Elena A. Krasnokutskaya,² Irina A. Perederyna,¹ and Viktor V. Zhdankin³

¹Department of Chemistry, Siberian State Medical University, Tomsk, Russia

²Department of Organic Chemistry, Tomsk Polytechnic University, Tomsk, Russia

³Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota, USA

A simple and environmentally safe general method of iodination of aromatic substrates under sovent-free conditions using the I₂/AgNO₃ combination in a solid state is reported.

Abstract

Synth. Commun. 2007, 37, 1267

CONVENIENT ONE-POT PREPARATION OF DIMETHYL BICYCLO[2.2.2]OCTANE-1,4,-DICARBOZYLATE, A KEY INTERMEDIATE FOR A NOVEL ADENOSINE A₁ RECEPTOR ANTAGONIST

HeXi Chang, William F. Kiesman, and Russell C. Petter

Department of Process Chemistry, Biogen Idec Inc., Cambridge, Massachusetts, USA

Abstract

Synth. Commun. 2007, 37, 1273

TOTAL SYNTHESES OF THE CHLORINATED β-CARBOLINE ALKALOIDS BAUERINE A, B, AND C

Berthold Pohl, Thomas Luchterhandt, and Franz Bracher

Department Pharmazie, Ludwig-Maximilians-Universität, Munich, Germany

The first total synthesis of the alkaloid bauerine C, as well as syntheses of bauerine A and bauerine B are presented.

Abstract

Synth. Commun. 2007, 37, 1281

CONVENIENT SYNTHESIS OF GEMINAL BISHYDROPEROXIDES BY THE REACTION OF KETONES WITH HYDROGEN PEROXIDE

A. O. Terent'ev, M. M. Platonov, Y. N. Ogibin, and G. I. Nikishin

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

Abstract

Synth. Commun. 2007, 37, 1289

HEMISYNTHESIS OF NEW TRITERPENE DERIVATIVES USING OXIDATION BY CRO₃ AND NAIO₄-(RUCL₃, 3H₂O)

N. Mazoir,¹ A. Auhmani,¹ M. Daoubi,¹ I.G. Collado,² and A. Benharref¹

¹Laboratoire de Chimie des Substances Naturelles, Département de Chimie, Faculté des Sciences, Université Cadi Ayyad, Marrakech, Maroc

²Departamento de Quίmica Orgánica, Facultad de Ciencias, Universidad de Cádiz, Cádiz, Spain

Triterpenic derivatives having carbonyl groups in positions 3, 7, 11, and 24 were synthesized with a good yields by treatment of compounds 1 and 10 with chromic anhydride (CrO₃) and the system NaIO₄-(RuCl₃, 3H₂O).

Abstract

Synth. Commun. 2007, 37, 1301

STRAIGHTFORWARD SYNTHESIS OF 2-ARYL-1-ALKYNYLPHOSPHONATES AND ARYLPROPIOLATES

Delphine Lecerclé, Céline Mothes, and Frédéric Taran

CEA, DSV, DBJC, SMMCB, Gif Sur Yvette, France

Abstract

Synth. Commun. 2007, 37, 1313

NOVEL UNCATALYZED HYDROCYANATION OF KETONES UTLIZING TETRACHLOROSILANE-POTASSIUM CYANIDE REAGENT

Tarek A. Salama, Saad S. Elmorsy, Abdel-Galel M. Khalil, Margret M. Girges, and Abdel-Aziz S. El-Ahl

Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt

Abstract

Synth. Commun. 2007, 37, 1321

ALKYLATION OF 3-PHENYL-1H-PYRAZOLO[4,3-c]QUINOLINE: THEORETICAL ANALYSIS OF REGIOSELECTIVITY

Timur I. Savchenko,¹ Olexiy V. Silin,² Sergiy M. Kovalenko,² Vladymir I. Musatov,³ Viktor M. Nikitchenko,¹ and Alexander V. Ivachtchenko⁴

¹V. N. Karazin's Kharkiv National University, Kharkiv, Ukraine

²Institute of Combinatorial Organic Chemistry, Kharkiv, Ukraine

³Institute for Single Crystals, Kharkiv, Ukraine

⁴ChemDiv, Inc., San Diego, USA

Abstract

Synth. Commun. 2007, 37, 1331

SYNTHESIS OF ANABASEINE AND ANABASINE DERIVATIVES: STRUCTURAL MODIFICATIONS OF POSSIBLE NICOTINIC AGONISTS

Eduardo Sobarzo-Sánchez,¹ Luis Castedo,¹ and Julio R. De la Fuente²

¹Department of Organic Chemistry and C.S.I.C. Associated Unit, Faculty of Chemistry, University of Santiago de Compostela, Santiago de Compostela, Spain

²Department of Organic and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Casilla, Santiago, Chile

Abstract

Synth. Commun. 2007, 37, 1339

MICROWAVE-PROMOTED EFFICIENT SYNTHESIS OF 3-(5-ARYLFURAN-2-YL)-6-ARYL/ARYLOXYMETHYLENE-1,2,4-s-TRIAZOLO[3,4-b]-1,3,4-THIADIAZOLES

Juan Liu¹ and Xi-Cun Wang²

¹College of Chemical Engineering, Northwest National University, Lanzhou, Gansu, China

²Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, China

Abstract

Synth. Commun. 2007, 37, 1347

SYNTHESIS OF NOVEL (P-SUBSTITUTED STYRYL) SPIROBENZOPYRANS

Rui-ren Tang,¹ Huang Kelong,¹ Zi-long Tang,² and Qing Yang¹

¹School of Chemistry and Chemical Engineering, Central South University, Changsha, China

²School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, China

A series of (p-substituted styryl) spirobenzopyrans were synthesized by the Wittig reaction of Fisher's bases with 5-(p-substituted styryl) salicylaldehyde derivatives. The final spirobenzopyrans were characterized by the ¹H NMR, IR, UV, and GC-MS analyses.

Abstract

Synth. Commun. 2007, 37, 1355

PALLADIUM-FREE COPPER-CATALYZED COUPLING REACTION OF ARYL IODIDES AND TERMINAL ACETYLENES IN WATER

Gong Chen, Xinhai Zhu, Jiwen Cai, and Yiqian Wan

School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, China

Abstract

Synth. Commun. 2007, 37, 1363

FACILE METHOD FOR TRIMETHYLSILYLATION OF ALCOHOLS USING HEXAMETHYLDISILAZANE AND AMMONIUM THIOCYANATE UNDER NEUTRAL CONDITIONS

Vrushali H. Jadhav, K. S. Ajish Kumar, Vinod D. Chaudhari, and Dilip D. Dhavale

Garware Research Centre, Department of Chemistry, University of Pune, Pune, India

Abstract

Synth. Commun. 2007, 37, 1371

MILD AND EFFICIENT METHOD FOR OXIDATIVE DEPROTECTION OF TRIMETHYLSILYL ETHERS MEDIATED BY TETRAETHYLAMMONIUM SUPEROXIDE

R. S. Raghuvanshi and K. N. Singh

Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India

Oxidative deprotection of trimethylsilyl ethers to their corresponding carbonyl compounds has been achieved under the mild reaction conditions of in situ generated tetraethylammonium superoxide.

Abstract

Synth. Commun. 2007, 37, 1375

ONE-POT SYNTHESIS OF BENZIMIDAZOLES FROM O-NITROANILINES UNDER MICROWAVES VIA A REDUCTIVE CYCLIZATION

Mandar P. Surpur, Pankajkumar R. Singh, Sachin B. Patil, and Shriniwas D. Samant

Organic Chemistry Research Laboratory, University Institute of Chemical Technology, Mumbai, India.

Abstract

Synth. Commun. 2007, 37, 1381

COPPER(II) BROMIDE: A SIMPLE AND SELECTIVE MONOBROMINATION REAGENT FOR ELECTRON-RICH AROMATIC COMPOUNDS

Suchitra Bhatt and Sandip K. Nayak

Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India

Abstract

Synth. Commun. 2007, 37, 1389

NEW ION-EXCHANGE CUM SEPARATION TECHNIQUE: A STUDY FOR THE SYNTHESIS OF ω-GUANIDINE CONTAINING PEPTIDES USING ω-AMINO ACID AS SURROGATES

Ashok K. Gangopadhyay and Bansi Lal

Medicinal Chemistry Department, Nicholas Piramal Research Centre, Goregaon (East), Mumbai, India

This article described a systematic study for the introduction of the ω-guanidine function at a late stage of synthesis of peptides, using a protected amino group as precursor. Further, we describe a unique salt exchange cum purification process.

Abstract

Synth. Commun. 2007, 37, 1421

SYNTHESIS OF 1-(2-HYDROXY-PHENYL)-3-PIPERIDIN-1-YL-PROPENONE BY ULTRASONIC IRRADIATION

N. R. Davli, S. N. Shelke, B. K. Karale, C. H. Gill*

P.G. Dept. of Chemistry, S.S.G.M. College, Kopargaon, Amednagar-423 601, India