Darzens Reaction Promoted by KF/Alumina: A Novel Stereoselective Method for Rapid and Efficient Synthesis of trans‐α,β‐Epoxy Ketones

Abstract

The Darzens condensation of α‐chloroacetophenone with various aromatic aldehydes mediated by potassium fluoride on alumina at room temperature resulted in formation of good to excellent yields of trans‐α,β‐epoxy ketones in short time periods.

Keywords:

• darzens reaction
• solid‐phase synthesis
• KF/alumina
• α, β-epoxy ketones

Acknowledgment

Partial financial support by the Ministry of Science, Research, and Technology of Iran is gratefully acknowledged.