Synthesis of α,ω‐Bis(oxazolidinone)polyoxyethylene via a Lithium Bromide–Catalyzed Reaction of Oligoethylene Glycol Diglycidyl Ethers with Isocyanates

Abstract

The synthesis of bis(oxazolidinone)polyoxyethylene derivatives 2a–h from oligoethylene glycols diglycidyl ethers 1a–e and isocyanates is reported. The reaction was achieved by lithium bromide and tributylphosphine oxide. These bis‐oxazolidinones may have important antibacterial activity.

Keywords:

• diglycidyl ethers
• isocynates
• lithium bromide
• oligoethylene glycols
• oxazolidinone

Acknowledgment

We thank J. Courtieu and F. Perez for HRMS data.