Graphical Abstracts

Graphical Abstracts Section

Synth. Commun. 2007, 37, 1765

PRACTICAL METHOD FOR 2-HYDROXYPHENYLKETIMINE SYNTHESIS

Minna T. Räisänen, Pertti Elo, Mika Kettunen, Martti Klinga, Markku Leskelä, and Timo Repo

Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland

Synth. Commun. 2007, 37, 1779

CATALYTIC OXIDATIVE CYCLOCONDENSATION OF O-AMINOPHENOLS TO 2-AMINO-3H-PHENOXAZIN-3-ONES

Mirosław Giurg, Katarzyna Piekielska, Magdalena Ge¸bala, Bartosz Ditkowski, Marcin Wolański, Wanda Peczyńska-Czoch, and Jacek Młochowski

Department of Organic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wrocław, Poland

Synth. Commun. 2007, 37, 1791

SYNTHESIS OF FUNCTIONALIZED PYRROLES BY REACTION OF 3,4‐DIACETYLHEXANE‐2,5‐DIONE WITH PRIMARY AMINES IN WATER

Issa Yavari and Maryam Sabbaghan

Department of Chemistry, Tarbiat Modarres University, Tehran, Iran

Synth. Commun. 2007, 37, 1801

HIGHLY EFFICIENT CYANOSILYLATION OF ALDEHYDES AND KETONES UNDER MICROWAVE, SOLVENT-FREE, AND LEWIS ACID–FREE CONDITIONS

Hirokazu Iida, Hiroshi Hamana, and Kiyoshi Matsumoto

Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba, Japan

The addition of TMSCN to aldehydes and ketones under microwave irradiation in the absence of any Lewis acid and solvent yielded the corresponding cyanohydrins in good yields in short reaction times (less than 30min).

Synth. Commun. 2007, 37, 1807

SOLVENT-FREE WILLIAMSON SYNTHESIS: AN EFFICIENT, SIMPLE, AND CONVENIENT METHOD FOR CHEMOSELECTIVE ETHERIFICATION OF PHENOLS AND BISPHENOLS

Ahmad R. Massah,¹ Masumeh Mosharafian,¹ Ahamad R. Momeni,¹ Hamid Aliyan,¹ Hamid Javaherian Naghash,¹ and Mohamd Adibnejad²

¹Department of Chemistry, Islamic Azad University, Shahreza, Isfahan, Iran

²Department of Chemistry, Islamic Azad University, Falavarjan, Isfahan, Iran

Synth. Commun. 2007, 37, 1817

SILICA CHROMATE AS A NOVEL OXIDIZING AGENT FOR THE OXIDATION OF 1,4-DIHYDROPYRIDINES

Mohammad Ali Zolfigol,¹ Peyman Salehi,² Arash Ghorbani Choghamarani,¹ Maliheh Safaiee,¹ and Mojgan Shahamirian¹

¹Chemistry Department, College of Science, Bu‐Ali Sina University, Hamadan, Iran

²Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehron, Iran

Synth. Commun. 2007, 37, 1825

DARZENS REACTION PROMOTED BY KF/ALUMINA: A NOVEL STEREOSELECTIVE METHOD FOR RAPID AND EFFICIENT SYNTHESIS OF TRANS-α,β-EPOXY KETONES

Ali Sharifi, Roghiyeh Salimi, Mojtaba Mirzaei, and M. Saeed Abaee

Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran

The Darzens condensation of α-chloroacetophenone with various aromatic aldehydes mediated by potassium fluoride on alumina at room temperature resulted in formation of good to excellent yields of trans-α,β-epoxy ketones in short time periods.

Synth. Commun. 2007, 37, 1833

RAPID AND EFFICIENT MICROWAVE‐ASSISTED SYNTHESIS OF N‐CARBOMAYL‐L‐AMINO ACIDS

Giancarlo Verardo, Paola Geatti, and Paolo Strazzolini

Dipartimento di Scienze e Tecnologie Chimiche, Università degli Studi di Udine, Udine, Italy

Synth. Commun. 2007, 37, 1845

SYNTHESIS OF 4-SUBSTITUTED- AND 1,4-DISUBSTITUTED-4-HYDROXYPYRROLIDIN-2-ONES

Christopher R. Kinsinger, Chad D. Tatko, Christopher M. Whelan, and Timothy J. Wilkinson

Chemistry Department, Wheaton College, Wheaton, Illinois, USA

Synth. Commun. 2007, 37, 1853

MILD METHOD FOR ULLMANN REACTION OF 2‐CHLOROBENZOIC ACIDS AND AMINOTHIAZOLES OR AMINOBENZOTHIAZOLES UNDER ULTRASONIC IRRADIATION

Rolando F. Pellón,¹ Maite L. Docampo,¹ and Mirta L. Fascio²

¹Centre of Pharmaceutical Chemistry, Havana, Cuba

²Buenos Aires University, Ciudad Autónoma de Buenos Aires, Argentina

One-pot syntheses of 5H-[1,3]thiazolo[2,3-b]quinazolin-5-one, 12H-[1,3]benzothiazolo[2,3-b]quinazolin-12-one, and corresponding derivatives were developed using the copper-catalyzed Ullmann condensation. The use of ultrasonic irradiation enhanced yields and reduced the reaction time to minutes.

Synth. Commun. 2007, 37, 1865

RADICAL ADDITION OF DIMETHYL 2-ETHYNYLCYCLOPROPANE-1,1-DICARBOXYLATE TO ELECTRON-RICH OLEFINS

Jeffrey H. Byers, Peter H. Goff, Nicholas J. Janson, Michael G. Mazzotta, and John E. Swigor

Department of Chemistry and Biochemistry, Middlebury College, Middlebury, Vermont, USA

The phenylseleno radical–catalyzed addition of dimethyl 2-ethynylcyclopropane-1,1-dicarboxylate to electron–rich olefins has been achieved.

Synth. Commun. 2007, 37, 1873

SIMPLE AND EFFICIENT SYNTHESIS OF 4,7‐DIMETHOXY‐1(H)‐INDENE

Xiang Zhang, Muralidhara Thimmaiah, and Shiyue Fang

Department of Chemistry, Michigan Technological University, Houghton, Michigan, USA

Stirring 2 in chloroform at room temperature in the presence of a catalytic amount of p-toluenesulfonic acid gave 1 in 95% yield. Other solvents, including benzene, which was the most frequently used one for this reason, gave mostly polymeric materials. The new method was also effective for dehydration of other electron-rich benzylic alcohols.

Synth. Commun. 2007, 37, 1879

SYNTHESIS OF A NOVEL N‐NITROALKYL BISINDOLYLMALEIMIDE

Sudipta Roy and Gordon W. Gribble

Department of Chemistry, Dartmouth College, Hanover, New Hampshire, USA

Synth. Commun. 2007, 37, 1887

PRACTICAL SYNTHESIS OF 4-FLUORO-2-(METHYLTHIO)BENZYLAMINE AND THE CORRESPONDING SULFONE AND SULFONAMIDE

Debra S. Perlow, Michelle S. Kuo, H. Marie Moritz, John S. Wai, and Melissa S. Egbertson

Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania, USA

Practical syntheses of 4-fluoro-2-(methylthio)benzylamine 1 and the corresponding 2-methylsulfonyl analog 2 were established. The methylthio moiety was introduced via either a regioselective lithiation or a selective nucleophilic aromatic substitution. The analogous sulfonamide 3 was prepared from 5-fluoro-2-methylbenzenesulfonyl chloride using standard chemical transformations.

Synth. Commun. 2007, 37, 1899

SYNTHESIS OF NOVEL HETEROBIFUNCTIONAL ISOCYANATO CROSS-LINKERS AND THEIR APPLICATIONS FOR THE PREPARATION OF 10-HYDROXYCAMPTOTHECIN AND SN-38 CONJUGATES WITH MELANOTRANSFERRIN P97

Zhong Li,¹ Dingqiao Yang,² Reinhard Gabathuler,³ and Qingqi Chen³

¹Department of Chemistry, University of Alabama, Tuscaloosa, Alabama, USA

²Department of Chemistry, South China Normal University, Guangzhou, China

³BioMarin Pharmaceutical Inc., Novato, California, USA.

Synth. Commun. 2007, 37, 1917

PEPTIDE SYNTHESIS WITH 5-AMINO-1-METHYL-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID

Elżbieta Masiukiewicz,¹ Barbara Rzeszotarska,¹ Irena Wawrzycka-Gorczyca,² and Edyta Kołodziejczyk³

¹Institute of Chemistry, University of Opole, Opole, Poland

²Faculty of Chemistry, Maria Curie-Skłodowska University, Lublin, Poland

³Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland

Synth. Commun. 2007, 37, 1927

NOVEL AND EFFICIENT SYNTHESIS OF 4-SUBSTITUTED-1,2,4-TRIAZOLIDINE-3,5-DIONES FROM ANILINES

Shadpour Mallakpour and Zahra Rafiee

Organic Polymer Chemistry Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan, Iran

Synth. Commun. 2007, 37, 1935

SYNTHESIS OF α,ω-BIS(OXAZOLIDINONE)POLYOXYETHYLENE VIA A LITHIUM BROMIDE–CATALYZED REACTION OF OLIGOETHYLENE GLYCOL DIGLYCIDYL ETHERS WITH ISOCYANATES

Lotfi Aroua and Ahmed Baklouti

Laboratory of Structural Organic Chemistry, Department of Chemistry, Faculty of Sciences of Tunis, Tunis, Tunisia

The synthesis of bis(oxazolidinone)polyoxyethylene derivatives 2a–h from oligoethylene glycols diglycidyl ethers 1a–e and isocyanates is reported. The reaction was achieved by lithium bromide and tributylphosphine oxide. These bis-oxazolidinones may have important antibacterial activity.