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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 13
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Original Articles

Synthesis of Novel Pyrrolo[1′,5′‐a]‐1,8‐naphthyridine Derivatives through a Facile One‐Pot Process

Xi‐Juan Zhao Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China; Graduate University of Chinese Academy of Sciences, Beijing, China
,
Yong Chen Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China; Graduate University of Chinese Academy of Sciences, Beijing, China
,
Wen‐Fu Fu Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China; Graduate University of Chinese Academy of Sciences, Beijing, China; College of Chemistry and Engineering, Yunnan Normal University, Kunming, ChinaCorrespondence[email protected]
&
Jia‐Bing Zhang College of Chemistry and Engineering, Yunnan Normal University, Kunming, China
Pages 2145-2152 | Received 16 Oct 2006, Published online: 03 Jul 2007
 
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Abstract

Novel pyrrolo[1′,5′‐a]‐1,8‐naphthyridine compounds have been synthesized through a facile one‐pot process by the reaction of the corresponding 1,8‐naphthyridines with aliphatic anhydride. The structures were established by spectroscopic data. Further X‐ray crystal analysis of 4′‐acetyl‐7‐methyl‐pyrrolo[1′,5′‐a]‐1,8‐naphthyridine (1) identifies its intriguing molecular structure and reveals the strong π‐π stacking.

Acknowledgment

We are grateful to the State Key Project (No. 2005CCA06800) for financial support. We thank the Foundation (50418010) for National Natural Science Foundation of China/Research Grants Council of Hong Kong (NSFC/RGC) Joint Research.

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