Efficient Synthesis of β‐Acetylamino Ketones using Silica‐Supported Sodium Hydrogen Sulfate as a Heterogeneous Catalyst

Abstract

Silica‐supported sodium hydrogen sulfate (NaHSO₄ · SiO₂) efficiently catalyzes the four‐component reaction of aryl aldehydes, enolisable ketones, acetyl chloride, and acetonitrile to form the corresponding β‐acetylamino ketones at room temperature. The catalyst is inexpensive and ecofriendly and works under heterogeneous conditions.The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times (1–3 h), and mild conditions.

Keywords:

• β‐acetylamino ketones
• heterogeneous catalyst
• short reaction times
• silica‐supported sodium hydrogen sulfate

Acknowledgment

The authors are thankful to M. Hari Babu, deputy director and head, Organic Chemistry Division II, IICT, for providing facilities and helpful discussions.