Synthesis of 3‐Heteroaryl‐Substituted Tetrahydrofurans from the Baylis–Hillman Adducts of Heteroarylaldehydes by n‐Bu₃SnH‐Mediated 5‐exo‐trig Vinyl Radical Cyclization

Abstract

The synthesis of 3‐heteroaryl‐substituted tetrahydrofurans from the propargyl derivative of Baylis–Hillman adducts of heteroaryl aldehydes by n‐Bu₃SnH‐mediated 5‐exo‐trig vinyl radical cyclization in high yield is reported.

Keywords:

• Baylis–Hillman adduct
• 5‐exo‐trig
• n‐Bu₃SnH
• tetrahydrofuran
• vinyl radical

Acknowledgments

The authors thank T. K. Chandrashekar, director, for providing infrastructure facilities. Financial support (SR/S1/OC‐38/2005) from the DST (New Delhi) is gratefully acknowledged. P. R., V. V., and B. V., thank the Council of Scientific and Industrial Research (CSIR) (New Delhi) for research fellowships. Thanks are due to Mrs. Viji for providing HRMS data.