Convenient and Efficient Method for the Obtainment of Ketones from Highly Hindered Aromatic N,N‐Dimethyl‐amides

Abstract

A simple and efficient procedure to synthesize highly hindered alkyl aryl ketones that involves the coupling of N,N‐dimethyl‐3,5‐di‐tert‐butylsalicylamide with organolithium compounds is described. Mild reaction conditions and good to excellent yields of the products are the noteworthy advantages of the procedure.

Keywords:

• acylphenols
• coupling reactions
• organolithium compound

Acknowledgments

This research was supported by the University of Concepción through the grant DIUC 205.023.041‐1.0.