Facile One‐Pot Synthesis of Oxazolidin‐2‐ones from Phenyl 2‐Hydroxyalkyl Selenides

Abstract

A novel, convenient, efficient, three‐step, one‐pot synthesis of 2‐oxazolidinones from phenyl 2‐hydroxyalkyl selenides was developed. Using this methodology, 2‐oxazolidinones are obtained in good yields (76–85%) by reaction of phenyl 2‐hydroxyalkyl selenides with benzoyl isocyanate and subsequent oxidation/cyclization, followed by hydrolysis with hydrochloric acid solution.

Keywords:

• one‐pot synthesis
• 2‐oxazolidinones
• phenyl 2‐hydroxyalkyl selenide

Acknowledgments

We gratefully acknowledge financial support from the National Natural Science Foundation of China (No. 20562005) and NSF of Jiangxi Province (No. 0620021).