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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 19
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Original Articles

Efficient Method for the Synthesis of Benzimidazoquinazoline Derivatives with Three‐Point DiversityFootnote

, &
Pages 3455-3470 | Received 15 Feb 2007, Published online: 05 Oct 2007
 

Abstract

An efficient strategy for the preparation of a novel heterocyclic ring system of benzimidazoquinazolines with three‐point diversity has been described. The compounds were obtained by treating o‐phenylene diamines with o‐nitrobenzaldehyde to give benzimidazoles, followed by reduction of the nitro group to give an amine. Derivatization of the resulting amine with isothiocyanates followed by in situ cyclodesulfurization at rt furnished the title compounds in high yields and purities.

Acknowledgment

B. Saha and S. Sharma are grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, for financial support.

Notes

CDRI Communication No. 7150.

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