Abstract
Graphical Abstract Section
Abstract
Synth. Commun. 2007, 37, 3273
FACILE SYNTHESIS OF BIBENZYL BY REDUCTIVE HOMOCOUPLING OF BENZYL HALIDES IN AQUEOUS MEDIA
Jian Liu and Bin Li
Department of Chemistry, Beijing Normal University, Beijing, China
A convenient and efficient synthesis of bibenzyl derivatives by reductive homocoupling reaction of benzyl halides using metallic iron powder in the presence of a catalytic amount of cuprous salt in water is described, which gives bibenzyl derivatives in good yields.
Abstract
Synth. Commun. 2007, 37, 3279
COPPER–FREE, EFFICIENT, PALLADIUM(II)–CATALYZED COUPLING OF UNACTIVATED ARYL IODIDES WITH TERMINAL ALKYNES
Tianrui Ren, Ye Zhang, Weiwen Zhu, and Jiaju Zhou
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China, and Graduate University of Chinese Academy of Sciences, Beijing, China
Palladium–catalyzed Sonogashira cross–coupling of unactivated aryl iodides with terminal alkynes.
Abstract
Synth. Commun. 2007, 37, 3291
ONE–POT DIRECT SYNTHESIS OF THIOCARBAMATES FROM ANILINE, CARBON MONOXIDE, AND THIOLS CATALYZED BY SELENIUM
Xiaopeng Zhang1,2 and Shiwei Lu2
1College of Chemistry and Environmental Science, Henan Normal University, Xinxiang, China
2National Engineering Research Center for Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
A mild and convenient method for the direct synthesis of thiocarbamates from aniline, carbon monoxide, and thiols catalyzed by selenium.
Abstract
Synth. Commun. 2007, 37, 3301
EUROPIUM TRIFLATE–CATALYZED ONE–POT SYNTHESIS OF 2,4,5–TRISUBSTITUTED–1H–IMIDAZOLES VIA A THREE–COMPONENT CONDENSATION
Chuanming Yu, Min Lei, Weike Su, and Yuanyuan Xie
College of Pharmaceutical Sciences, Zhejiang University of Technology, Zhejiang Key Laboratory of Pharmaceutical Engineering, Hangzhou, China
A simple, efficient, and practical procedure for the condensation of benzoin or acetoin, aromatic aldehydes, and ammonium acetate using europium triflate [Eu(OTf)3] as a novel catalyst in high yields is described. The catalyst can be recovered conveniently and reused at least four times without any loss of activity.
Abstract
Synth. Commun. 2007, 37, 3311
TOTAL SYNTHESIS OF NEUROPROTECTIVE DICTYOQUINAZOL A, B, AND C
Chang Ho Oh and Chung Hyun Song
Department of Chemistry, Hanyang University, Sungdong–Gu, Seoul, Korea
A new protective compound, dictyoquinazol A, was synthesized starting from 5–methoxy–2–nitrobenzoic acid in six steps in 36% overall yield. Two derivatives B and C, isolated from the mushroom Dictyophora indusiata, were also synthesized from Dictyoquinazole A.
Abstract
Synth. Commun. 2007, 37, 3319
STUDY ON THE SYNTHESIS AND BIOACTIVITY OF NOVEL MAHKOSIDE A DERIVATIVES
Yan–Bing Zhang, Pi–Yong Zhang, Gui–Fu Dai, and Hong–Min Liu
Department of Chemistry, New Drug Research and Development Center, Zhengzhou University, Zhengzhou, China
A series of novel Mahkoside A derivatives was reported, and the structure–activity relationship was analyzed.
Abstract
Synth. Commun. 2007, 37, 3329
SOLVENT–FREE SYNTHESIS OF BENZOTHIAZOLINES IN THE PRESENCE OF ALUMINA
Mitsuo Kodomari,1 Akihito Satoh,1 Ryo Nakano,1 and Tadashi Aoyama2
1Department of Applied Chemistry, Shibaura Institute of Technology, Koto–ku, Tokyo, Japan
2Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda–ku, Tokyo, Japan
Abstract
Synth. Commun. 2007, 37, 3337
EXPEDITIOUS SYNTHESIS OF NEW 3,4,6–TRIHYDROXYTHIEPANES FROM D–(–)–QUINIC ACID
Tzenge–Lien Shih and Yi–Chuan Fang
Department of Chemistry, Tamkang University, Tamsui, Taipei County, Taiwan, Republic of China
Abstract
Synth. Commun. 2007, 37, 3351
SCANDIUM TRIFLATE–PROMOTED ADDITION OF ORGANOZINC REAGENTS TO BENZALDIMINETRICARBONYLCHROMIUM DERIVATIVES
Kaori Ishimaru, Kyoto Ohe, and Takakazu Kojima
Department of Chemistry, National Defense Academy, Hashirimizu, Yokosuka, Japan
Abstract
Synth. Commun. 2007, 37, 3359
P D/C: A RECYCLABLE CATALYST FOR CYANATION OF ARYL HALIDES WITH K4[FE(CN)6]
Yi–Zhong Zhu and Chun Cai
Chemical Engineering College, Nanjing University of Science and Technology, Nanjing, China
Abstract
Synth. Commun. 2007, 37, 3367
SYNTHESIS OF PIPERIDINE DERIVATIVES BY REDUCTION OF PYRIDINIUM SALTS
Zilong Tang,1,2 Joelle Mayrargue,1 and Mouad Alami2
1Faculty of Pharmacy, Department of Chemistry, University of Paris–Sud, Chatenay–Malabry Cedex, France
2School of Chemistry and Chemical Engineering, Hunan Provincial University Key Laboratory of QSAR/QSPR, Hunan University of Science and Technology, Xiangtan, China
A series of unsaturated piperidines was prepared in moderate to excellent yields by the reduction of the corresponding pyridinium salts with NaBH4 in methanol.
Abstract
Synth. Commun. 2007, 37, 3381
CE(SO4)2–MEDIATED NITRATION OF N,N–DIALKYLANILINES WITH NANO2 IN WATER
Xianghua Yang and Chanjuan Xi
Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China
Abstract
Synth. Commun. 2007, 37, 3393
PRACTICAL SYNTHESIS OF NEW β‐ DIKETONE‐CONNECTED BIPYRIDINE AND ITS CONVERSION TO PYRAZOLE‐CENTERED BIPYRIDINE LIGAND
Wei Zhang,1 Jianhui Liu,1 Hongjun Zhu,1 Weiming Gao,1 and Licheng Sun1,2
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China
2Department of Chemistry, Organic Chemistry, Royal Institute of Technology (KTH), Stockholm, Sweden
Abstract
Synth. Commun. 2007, 37, 3403
EFFICIENT AND CONVENIENT ONE–POT, SYNTHESIS OF PHOSPHORAMIDATES AND PHOSPHATES
A. K. Gupta, J. Acharya, D. K. Dubey, and M. P. Kaushik
Process Technology Development Division, Defence Research and Development Establishment, Gwalior, India
Abstract
Synth. Commun. 2007, 37, 3409
IMPROVED SYNTHESIS OF GEFITINIB AND ERLOTINIB HYDROCHLORIDE– ANTICANCER AGENTS
Venkateshappa Chandregowda, Gudapati Venkateswara Rao, and Goukanapalli Chandrasekara Reddy
Vittal Mallya Scientific Research Foundation, Bangalore, India
Abstract
Synth. Commun. 2007, 37, 3417
RAPID, CHEMOSELECTIVE AND FACILE SYNTHESIS OF AZINES BY HYDRAZINE/I2
H. M. Nanjundaswamy1 and M. A. Pasha2
1Chemical Examination Section, Public Health Institute, Bangalore, India
2Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, India
We report the reaction of hydrazine hydrate with carbonyl compounds in the presence of molecular iodine at 0–10°C, which affords symmetrical azines in excellent yields in 1 to 4 min without any adverse effect on other substituents. The reactions are rapid and chemoselective, afford excellent yields, and have high–purity products. The workup procedure is environmentally benign and does not require solvent extraction.
Abstract
Synth. Commun. 2007, 37, 3421
REGIOSELECTIVE PHOTOCHEMICAL AND MICROWAVE–MEDIATED MONOBROMINATION OF AROMATIC COMPOUNDS USING 2,4,4,6–TETRABROMO–2,5–CYCLOHEXADIENONE
Neeraj Gupta,1 Goverdhan L. Kad,1 Vasundhara Singh,2 and Jasvinder Singh1
1Department of Chemistry, Punjab University, Chandigarh, India
2Department of Applied Sciences, Punjab Engineering College (Deemed University), Chandigarh, India
Abstract
Synth. Commun. 2007, 37, 3429
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1–[(SUBSTITUTED CARBAMOYL)AMINO] –1H,3H–1λ5–[1,3,2] OXAZAPHOSPHOLO[3,4–A] BENZIMIDAZOL–1–ONES
U. Anasuyamma, P. Haranath, M. Anil Kumar, C. Suresh Reddy, and C. Naga Raju
Department of Chemistry, Sri Venkateswara University College of Engineering, Tirupati, India
1–[(Substituted carbamoyl)amino] –1H,3H–1λ5–[1,3,2] oxazaphospholo[3,4–a] benzim–idazol–1–ones (5a–j) were synthesized by reacting benzimidazole 2–methanol (4) with different chlorides of carbamidophosphoric acids (3) in the presence of triethylamine at 40–45°C. Their 1H, 13C, and 31P NMR spectral data were discussed. The title compounds were tested for their activity against the fungi Aspergillus niger and Fusarium solani and bacteria Staphylococcus aureus and Escherichia coli. These compounds showed moderate antibacterial activity when compared with antifungal activity.
Abstract
Synth. Commun. 2007, 37, 3439
EFFICIENT SYNTHESIS OF (1R)–[3,5–BIS(TRIFLUOROMETHYL)PHENYL] ETHANOL, A KEY INTERMEDIATE FOR APREPITANT, AN NK–1 RECEPTOR ANTAGONIST
Pravinchandra J. Vankawala,1 Naveenkumar Kolla,1 Chandrashekar R. Elati,1 M. Sreenivasulu,2 K. Arun Kumar,2 Yerrimilli Anjaneyulu,3 Sundaram Venkatraman,1 Apurba Bhattacharya,1 and Vijayavitthal T. Mathad1
1Research and Development, Dr. Reddy's Laboratories Ltd., Bollaram, India
2Department of Custom Chemical Service, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad, Andhra Pradesh, India
3Center for Atmospheric Science, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Andhra Pradesh, India
Abstract
Synth. Commun. 2007, 37, 3447
EFFICIENT AND GREEN METHOD FOR THE SYNTHESIS OF 1,5–BENZODIAZEPINE AND QUINOXALINE DERIVATIVES IN WATER
Parasa Hazarika, Pranjal Gogoi, and Dilip Konwar
Synthetic Organic Chemistry Division, Regional Research Laboratory, Jorhat, Assam, India
Abstract
Synth. Commun. 2007, 37, 3455
EFFICIENT METHOD FOR THE SYNTHESIS OF BENZIMIDAZOQUINAZOLINE DERIVATIVES WITH THREE–POINT DIVERSITY
Biswajit Saha, Sunil Sharma, and Bijoy Kundu
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India