Use of Di‐tert‐butyl‐dicarbonate Both as a Protecting and Activating Group in the Synthesis of Dipeptides

Abstract

Amide formation from amino acids was achieved in an easy and convenient one‐pot procedure using di‐tert‐butyl dicarbonate both as a protecting and an activating agent. A number of dipeptides have been synthesized in good yields.

Keywords:

• activation of carboxylic group
• amide formation
• amino protecting group
• di‐tert‐butyl‐dicarbonate

Acknowledgments

We thank J. Joule (Manchester University) for obtaining the mass spectra. We thank both J. Joule and B. Novak and for their constructive comments.