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Short and efficient synthesis of rubrolide E from commercially available 4‐methoxyacetophenone, employing ring‐closing metathesis, Knoevenagel condensation, and Reformatsky reactions, are the key steps are described.
A. B. P. thanks Council of Scientific and Industrial Research (CSIR), New Delhi, India, for a fellowship, and S. P. C. thanks Department of Science and Technology (DST), New Delhi, India, for funding.
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