Microwave‐Assisted Rapid and Straightforward Synthesis of Novel 6‐(Aroxymethyl)‐2‐aryl‐6,7‐dihydropyrazolo[5,1‐c][1,4]oxazin‐4‐one Derivatives

Fang Wei Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, China

Bao‐Xiang Zhao Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, ChinaCorrespondence[email protected]

Wen‐Liang Dong Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, China

Hua Zuo Department of Chemistry, Changwon National University, Changwon, Korea

Dong‐Soo Shin Department of Chemistry, Changwon National University, Changwon, Korea

Da‐Wei Wang Shandong Center for Disease Control and Prevention, Jinan, China

Yong Xia Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, China

Yan‐Qing Ge Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, China

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Abstract

A series of novel 6‐(aroxymethyl)‐2‐aryl‐6,7‐dihydropyrazolo[5,1‐c][1,4] oxazin‐4‐one derivatives was synthesized from ethyl 3‐aryl‐1H‐pyrazole‐5‐carboxylate and 2‐aryloxymethylepoxide by a microwave‐assisted, one‐step method in good yields. The microwave‐assisted reaction of ethyl 3‐aryl‐1H‐pyrazole‐5‐carboxylate and 2‐aryloxymethylepoxide proceeds with higher regioselectivity and is more economical and environmentally friendly in contrast to the normal intramolecular esterification route. A tandem mechanism of the reaction was proposed.

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Acknowledgments

This study was supported by the Foundation of the Ministry of Education (104112) and the Natural Science Foundation of Shandong Province (Y2005B12).

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Microwave‐Assisted Rapid and Straightforward Synthesis of Novel 6‐(Aroxymethyl)‐2‐aryl‐6,7‐dihydropyrazolo[5,1‐c][1,4]oxazin‐4‐one Derivatives

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Microwave‐Assisted Rapid and Straightforward Synthesis of Novel 6‐(Aroxymethyl)‐2‐aryl‐6,7‐dihydropyrazolo[5,1‐c][1,4]oxazin‐4‐one Derivatives

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