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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 24
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Original Articles

Cerium(III) Chloride: A Highly Efficient Reagent for the Synthesis of α‐Aminonitriles

M. A. Pasha Department of Studies in Chemistry, Bangalore University, Bangalore, IndiaCorrespondence[email protected]
,
H. M. Nanjundaswamy Chemical Examination Section, Public Health Institute, Bangalore, India
&
V. P. Jayashankara Department of Studies in Chemistry, Bangalore University, Bangalore, India
Pages 4371-4380 | Received 21 May 2007, Published online: 14 Dec 2007
 
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Abstract

We report a highly efficient, one‐pot, three‐component condensation of carbonyl compounds, amines, and TMSCN in MeCN; the reaction is significantly promoted by the catalytic amount of cerium(III) chloride at ambient temperature in excellent yields without any adverse effect on the other substituents. The method afforded an elegant alternative to the synthesis of α‐aminonitriles. The reactions are fast and clean, and the products obtained are of high purity.

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